Adfolic OD
SUPPLEMENT FACTS
DESCRIPTION:
Benefits of taking Adfolic tablet
Ist Generation Folic acid:
Food folate: Refers to the various tetrahydrofolate derivatives Naturally present in foods.
2nd Generation - Folic acid:
• it's a man-made oxidized molecule that does not occur in nature but could also be utilized by the build as a precursor to form natural folates that are biologically active.
• B lacks coenzyme activity and must be reduced to the metabolically active form within the cell, through a series of biochemical steps before it are often utilized by the body's cells in vital metabolic pathways like DNA production, cell reproduction, and homocysteine metabolism.
3rd Generation Folic acid:
(6S)-5-methyltetrahydrofolate calcium salt:
• The calcium salt of (6S)-5-methyltetrahydrofolate is out there commercially and represents the third generation of vitamin B complex. Until now, (6S)-5-methyltetrahydrofolate calcium salt was the only real B derivative available on the market, and prepared to penetrate the body cells with no need further metabolism.
4th Generation Folic acid:
Quatrefolie, (6S)-5-methyltetrahydrofolate glucosamine salt: Quatrefolic" is that the glucosamine salt of (6S)-5-methyltetrahydrofolate and is structurally analogous to the reduced and active form of vitamin B complex. Quatrefolic stability additionally as peculiarly high water solubility, improved bioavailability, and well-established safety.CLINICAL PHARMACOLOGY
The Mechanism of action of Quatrefolic is expounded to the action of 5-methyltetrahydrofolate the active a component of the proprietary ingredient.
5- methyltetrahydrofolate derives from tetrahydro folic acid, Through a series of metabolic Reactions.
Tetrahydrofolic acid acts as a coenzyme in several vital metabolic reactions participating within the transfer as acceptors and donors of varied one-carbon fragments, involved within the biosynthesis of nucleotides purines and pyrimidines, and thus the metabolism of several important amino acids.
In concern with vitamin B, folate coenzymes allow the conversion of the compound homocysteine to methionine, the dearth of this conversion has been associated with various pathologies and diseases.
Conversion of tetrahydrofolic acid to 5-methylltetrahy- drofolate is mediated by the action of the enzyme methyltetrahydrofolate reductase.
Supplementation with 5-methyltetrahydrofolate may well be preferable to B, being it's immediately available to react with homocysteine to avoid the possibility of hyperhomocysteinemia.
Adfolic OD tablet INDICATIONS
• During pregnancy and lactation
• pregnant women for prevention of ectoderm defects in babies
• As a dietary supplement in adults and older people to forestall the danger of spontaneous abortions
• In hyperhomocysteinemia
• Folate deficiency caused by some medicines (e.g. those used to treat epilepsy like phenytoin, phenobarbital, and primidone)
• Folate deficiency caused by long-term red vegetative cell damage or kidney dialysis
• In Depression, Cognitive impairment, Dementia, and Alzheimer's
DOSAGE AND ADMINISTRATION
The intended uses of Quatrefolic" and use levels are the identical as that of B, expressed on the bases of the "Recommended Dietary Allowances for Folate in Children and Adults"
CONTRAINDICATIONS
Long-term folate therapy IS contraindicated in any patient with untreated ad cobalamin deficiency.
this may be untreated anaemia or other reason behind cobalamin deficiency, including lifelong vegetarians.
In elderly people, a cobalamin absorption test should be done before long-term folate therapy, Folate given to such patients for 3 months or longer has precipitated cobalamin neuropathy. No harm has occurréd from short course of folate
• Folic acıd should never be alone within the treatment of Addisonian. anaemia and other antipernicious anemia factor deficiency states because it should precipitate the onset of subacute combined degeneration of the neural structure
• Folic acıd should not be employed in malıgnant discase unless pernicious anaemia due to folate deficiency may be a crucial complication.
• Known hypersensitivity to the active ingredient
WARNINGS AND PRECAUTIONS
• Patients with Vitamın B12 deficiency mustn't be treated with folacin unless administered with adequate amounts of hydmsncobalamın, because it can mask the condition but the subacute irreversible damage to the system will continue The deficiency are actually because of undiagnosed anaemia including in infancy, anemia or macrocytic anemia of unknown etiology or other explanation for cobalamin deficiency, including lifelong vegetarians.
• Caution should be exercised when administering vitamin B to patients who may have folate-dependent tumors.
• This product isn't intended for healthy pregnant women where lower doses are recommended, apart from pregnant women with B deficiency or women at risk for the reoccurrence of ectoderm defects.
• Taking folic acid supplements might make seizures worse in people with seizure disorders, particularly in high doses.
• Pregnant or breast-feeding women shall consult a health care professional before use
ADVERSE REACTIONS
DRUG INTERACTIONS
Fosphenytoin vitamin B along with fosphenytoin might decrease the effectiveness of fosphenytoin for preventing seizures.
Methotrexate B along with methotrexate might decrease the effectiveness of methotrexate Phenobarbital Folic acid can decrease the phenobarbital effect for preventing seizures.
Phenytoin vitamin BC along with phenytoin might decrease the effectiveness of phenytoin and increase the possibility of seizures.
Primidone B-complex vitamin along with primidone might decrease how well primidone works for preventing seizures.
Pyrimethamine folacin might decrease the effectiveness of pyrimethamine for treating parasite infections. Sulfasalazine can reduce the absorption of B complex
USE IN SPECIAL POPULATIONS
Pregnancy US FDA Pregnancy Category A. B vitamin is perhaps going safe when taken orally appropriately during pregnancy Taking 600 mcg of vitamin B complex daily is usually used during pregnancy to forestall birth defects and some ectoblast defects.
Nursing mothers' B is actively excreted into human milk.
No adverse effects in nursing infants are associated with the employment of B vitamin during lactation.
OVER DOSE & TREATMENT:
No information is available regarding the overdose of Quatrefolic.
however for folic acid. No special procedures or Antidotes are likely To be needed.
PRESENTATION Adfoic 300mcg Box of 30 Tablets Adfolic OD 600mcg: Box of 30 Tablets
INSTRUCTIONS Store below 30°C. Protect from sunlight, heat, and moisture. Keep out of the
reach of children.
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